LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic

0349854 - ÚMG 2011 RIV GB eng J - Článek v odborném periodiku
Hořejší, Václav - Otáhal, Pavel - Brdička, Tomáš
LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic.
FEBS Journal. Roč. 277, č. 21 (2010), s. 4383-4397. ISSN 1742-464X. E-ISSN 1742-4658
Grant CEP: GA ČR GEMEM/09/E011; GA MŠMT 1M0506
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: LAT * transmembrane adaptor protein * membrane rafts
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.129, rok: 2010

Membrane rafts are microdomains involved in a number of biologically important processes, including immunoreceptor signalling. Among the functionally important protein components of these microdomains are transmembrane adaptor proteins, containing in their intracellular domains tyrosine residues that can be phosphorylated and bind other cytoplasmic signalling proteins. The most important leukocyte transmembrane adaptor protein is LAT (linker for activation of T cells), which is critically involved in T cell receptor signalling, but also plays important roles in signal initiation by several other immunologically important receptors. Here we review recent progress in the elucidation of several aspects of this protein, e.g. the controversy concerning the importance of LAT being present in membrane rafts, the involvement in signalling through a number of receptors other than the T cell receptor and the puzzling phenotype of some LAT mutants.
Trvalý link: http://hdl.handle.net/11104/0189989