A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

0348257 - FGÚ 2011 RIV GB eng J - Článek v odborném periodiku
Heinig, M. - Petretto, E. - Wallace, C. - Bottolo, L. - Rotival, M. - Lu, H. - Li, Y. - Sarwar, R. - Langley, S. R. - Bauerfeind, A. - Hummel, O. - Lee, Y. A. - Paskas, S. - Rintisch, C. - Saar, K. - Cooper, J. - Buchan, R. - Gray, C. C. - Cyster, J. G. - Erdmann, J. - Hengstenberg, C. - Maouche, S. - Ouwehand, W. H. - Rice, C. M. - Samani, N. J. - Schunkert, H. - Goodall, A. H. - Schulz, H. - Roider, H. G. - Vingron, M. - Blankenberg, S. - Münzel, T. - Zeller, T. - Szymczak, S. - Ziegler, A. - Tiret, L. - Smyth, D. J. - Pravenec, Michal - Aitman, T. J. - Cambien, F. - Clayton, D. - Todd, J. A. - Hubner, N. - Cook, S.A.
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Nature. Roč. 467, č. 7314 (2010), s. 460-464. ISSN 0028-0836. E-ISSN 1476-4687
Grant CEP: GA MŠMT(CZ) 1M0520; GA ČR GAP301/10/0290
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: IRF7 driven inflammatory network * Ebi2 * type 1 diabetes
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 36.104, rok: 2010

Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF73)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein–Barr virus induced gene 2 (Ebi2), which lies at this locus and controls B lymphocyte migration is expressed in macrophages and regulates the IDIN. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D). These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D
Trvalý link: http://hdl.handle.net/11104/0188834