Pooled analysis of studies on DNA adducts and dietary vitamins

0347678 - ÚEM 2011 RIV NL eng J - Článek v odborném periodiku
Ragin, C. - Minor, A. - Agudo, A. - Farmer, P. - Garte, S. - Gonzales, C. - Kalina, I. - Matullo, G. - Popov, T. - Palli, D. - Peluso, M. - Ricceri, F. - Šrám, Radim - Vineis, P. - Taioli, E.
Pooled analysis of studies on DNA adducts and dietary vitamins.
Mutation Research-Reviews in Mutation Research. Roč. 705, č. 2 (2010), s. 77-82. ISSN 1383-5742. E-ISSN 1388-2139
Grant ostatní: EU(XE) FOOD-CT-2005-513943
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: biomarkers * carcinogenicity * molecular epidemiology
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 8.741, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0347678_01.pdf

The study investigates the association between vitamins, DNA adducts environmentally induced by carcinogens, and smoking. It was found that vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamin A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only. These results are relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention.
Trvalý link: http://hdl.handle.net/11104/0188407