Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine

0347210 - FGÚ 2011 RIV GB eng J - Článek v odborném periodiku
Špicarová, Diana - Paleček, Jiří
Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine.
Journal of Neuroinflammation. Roč. 7, - (2010), s. 49-7. E-ISSN 1742-2094
Grant CEP: GA MŠMT(CZ) LC554; GA ČR GA305/09/1228
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: TNF * TRPV1 * pain
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 5.785, rok: 2010

In our experiments the possible influence of TNFa on presynaptic spinal cord TRPV1 receptor function was investigated. Our results indicate that TNFa may have a significant impact on nociceptive signaling at the spinal cord level that could be mediated by increased responsiveness of presynaptic TRPV1 receptors to endogenous agonists. This could be of major importance, especially during pathological conditions, when increased levels of TNFa and TNFR are present in the spinal cord
Trvalý link: http://hdl.handle.net/11104/0188038