Channel character of uncoupling protein-mediated transport

0344047 - FGÚ 2011 RIV GB eng J - Článek v odborném periodiku
Ježek, Petr - Jabůrek, Martin - Garlid, K. D.
Channel character of uncoupling protein-mediated transport.
FEBS Letters. Roč. 584, č. 10 (2010), s. 2135-2141. ISSN 0014-5793. E-ISSN 1873-3468
Grant CEP: GA ČR(CZ) GA303/07/0105; GA MŠMT ME09018
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: mitochondrial uncoupling protein * anion uniport * eyring barrier model
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.601, rok: 2010

An existence of pure proton channel in UCPs is excluded by the equivalent flux-voltage dependencies for uniport of FAs and halide anions, which are best described by the Eyring barrier variant with a single energy well in the middle of two peaks. We suggest that UCPs took advantage of the common FA-uncoupling function of SLC25 family carriers and dropped their solute transport function
Trvalý link: http://hdl.handle.net/11104/0186366