The reduction of doxorubicin at a mercury electrode and monitoring its interaction with DNA using constant current chronopotentiometry

0343810 - BFÚ 2011 RIV CZ eng J - Článek v odborném periodiku
Vacek, J. - Havran, Luděk - Fojta, Miroslav
The reduction of doxorubicin at a mercury electrode and monitoring its interaction with DNA using constant current chronopotentiometry.
Collection of Czechoslovak Chemical Communications. Roč. 74, 11-12 (2009), s. 1727-1738. ISSN 0010-0765
Grant CEP: GA ČR(CZ) GA203/07/1195; GA MŠMT(CZ) LC06035; GA AV ČR(CZ) 1QS500040581
Grant ostatní: GA AV ČR(CZ) IAA400040903
Program: IA
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: doxorubicin * mercury electrode * chronopotentiometry
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 0.856, rok: 2009

Voltammetry with linear scan and chronopotentiometric stripping (CPS) with constant current were used for the analysis of doxorubicin (DOX) at the hanging mercury drop electrode. CPS was used for the study of DOX in situ electrochemical reduction in adsorbed state and for ex situ (adsorptive transfer) analysis of the drug. The CPS method was also applied to monitor the DOX interaction with double- and single-stranded DNA.
Trvalý link: http://hdl.handle.net/11104/0186199