Počet záznamů: 1
Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex
- 1.0342964 - BC 2011 RIV DE eng J - Článek v odborném periodiku
Kubíček, K. - Monnet, J. - Scintilla, S. - Kopečná, Jana - Arnesano, F. - Trantírek, Lukáš - Chopard, C. - Natile, G. - Kozelka, J.
Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex.
Chemistry-An Asian Journal. Roč. 5, č. 2 (2010), s. 244-247. ISSN 1861-4728. E-ISSN 1861-471X
Grant ostatní: GA ČR(CZ) GP202/08/P416
Program: GP
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: DNA structures * interstrand crosslinks * molecular modeling * NMR spectroscopy * platinum
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.188, rok: 2010
An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-diaminocyclohexane)2+ (the enantiomer of the antitumor drug oxaliplatin). The final product provides a rare example of intramolecular self-intercalation of DNA.
Trvalý link: http://hdl.handle.net/11104/0185561
Počet záznamů: 1