Thermoresponsive micelles for radionuclide delivery

0342223 - ÚMCH 2011 RIV NL eng C - Konferenční příspěvek (zahraniční konf.)
Hrubý, Martin - Filippov, Sergey K. - Pánek, Jiří - Nováková, Michaela - Macková, Hana - Kučka, Jan - Ulbrich, Karel
Thermoresponsive micelles for radionuclide delivery.
Abstract Book. Egmond aan Zee: University of Twente, 2010 - (Engbersen, J.), s. 216-218. ISBN 978-90-365-3007-1.
[European Symposium on Controlled Drug Delivery /11./. Egmond aan Zee (NL), 07.04.2010-09.04.2010]
Grant CEP: GA AV ČR KAN200200651; GA MŠMT 1M0505; GA ČR GPP207/10/P054
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: micelles * drug delivery systems * thermoresponsive polymers
Kód oboru RIV: FR - Farmakologie a lékárnická chemie

We have synthesized and characterized a thermoresponsive micellar radionuclide delivery systems based on ABA triblock copolymers poly[2-methyl-2-oxazoline - block - (2-isopropyl-2-oxazoline - co - 2-butyl-2-oxazoline) - block - 2-methyl-2-oxazoline]. These polymers are molecularly dissolved in aqueous millieu below cloud point temperature (CPT) of the thermoresponsive central block and above its CPT they form polymer micelles with diameter ~ 200 nm. A phenolic moiety introduced into the copolymer allowed radionuclide labeling with 125I ongoing in good yield with sufficient in vitro stability under model conditions.
Trvalý link: http://hdl.handle.net/11104/0185016