Polymorphism -23HPhI in the Promoter of Insulin Gene and Pancreatic Cancer: A Pilot Study

0338843 - ÚI 2010 RIV SK eng J - Článek v odborném periodiku
Krechler, T. - Jáchymová, M. - Pavlíková, Markéta - Vecka, M. - Zeman, M. - Krška, Z. - Švestka, J. - Žák, A.
Polymorphism -23HPhI in the Promoter of Insulin Gene and Pancreatic Cancer: A Pilot Study.
Neoplasma. Roč. 56, č. 1 (2009), s. 26-32. ISSN 0028-2685. E-ISSN 1338-4317
Grant ostatní: GA MZd(CZ) NR9528
Výzkumný záměr: CEZ:AV0Z10300504
Klíčová slova: pancreatic cancer * insulin gene regulation * polymorphism of -23HphI * diabetes mellitus * disorders of glucoregulation
Kód oboru RIV: FD - Onkologie a hematologie
Impakt faktor: 1.192, rok: 2009

Pancreatic cancer (PC) is one of the most frequent gastrointestinal malignancies with extremely poor prognosis. 11, spite of a relative low incidence of PC, in comparison with other cancers, PC is the fourth leading Cause of cancer death in USA in both sexes. The available data clearly suggest that diabetes mellitus (DM) can be both a long-standing cause of PC and an early manifestation of the disease. Besides of DM, insulin resistance and high insulin levels arc linked as well with increased cancer risk, including PC.
Trvalý link: http://hdl.handle.net/11104/0182506