In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives

0337442 - ÚOCHB 2010 RIV US eng J - Článek v odborném periodiku
Evangelou, A. - Zikos, C. - Benaki, D. - Pelecanou, M. - Bouziotis, P. - Papadopoulos, M. - Borovičková, Lenka - Veselá, Iva - Elbert, Tomáš - Kunešová, G. - Pirmettis, I. - Paravatou-Petsotas, M. - Slaninová, Jiřina - Livaniou, E.
In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.
Peptides. Roč. 30, č. 12 (2009), s. 2409-2417. ISSN 0196-9781. E-ISSN 1873-5169
Grant CEP: GA MŠMT ME 872
Grant ostatní: Czech-Greek Joint Research and Technology Programme(GR) 188-gamma
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: neuroprotective peptides * humanin derivatives * [125I] radiolabeling
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.705, rok: 2009

Four new, tyrosine containing humanin derivatives were synthesized, the neuroprotective action was evaluated in the T-maze test and the most active ones were radiolabeled with 125I. Under the experimental conditions used, our data do not confirm the existence of specific binding sites for humanin on the neuronal tissue.
Trvalý link: http://hdl.handle.net/11104/0181434