Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility

0334121 - ÚMG 2010 RIV DE eng J - Článek v odborném periodiku
Lipoldová, Marie - Havelková, Helena - Badalová, Jana - Vojtíšková, Jarmila - Quan, L. - Krulová, Magdalena - Sohrabi, Yahya - Stassen, A. P. M. - Demant, P.
Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility.
Cancer Immunology and Immunotherapy. Roč. 59, č. 2 (2010), s. 203-213. ISSN 0340-7004. E-ISSN 1432-0851
Grant CEP: GA MŠMT(CZ) LC06009; GA AV ČR IAA500520606; GA ČR GD310/08/H077
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: Tumor susceptibility * Genetic control of interferon gamma production * Lymphocyte infiltration of tumors
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.293, rok: 2010

Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth.
Trvalý link: http://hdl.handle.net/11104/0178940