Replication of Restless Legs Syndrome Loci in Three European Populations

0331384 - ÚEM 2010 RIV GB eng J - Článek v odborném periodiku
Kemlink, D. - Polo, O. - Frauscher, B. - Gschliesser, V. - Högl, B. - Poewe, W. - Vodička, Pavel - Vávrová, J. - Šonka, K. - Nevšímalová, S. - Schormair, B. - Lichtner, P. - Silander, K. - Peltonen, L. - Gieger, C. - Wichmann, H. E. - Zimprich, A. - Roeske, D. - Müller-Myhsok, B. - Meitinger, T. - Winkelmann, J.
Replication of Restless Legs Syndrome Loci in Three European Populations.
Journal of Medical Genetics. Roč. 46, č. 5 (2009), s. 315-318. ISSN 0022-2593. E-ISSN 1468-6244
Grant CEP: GA MZd NR8563
Grant ostatní: GA MŠk(CZ) MSM0021620816
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: periodic limb movements * genetic risk-factor * susceptibility locus
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 5.751, rok: 2009

Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. Our study shows that variants in these three loci confer consistent disease risks in patients of European descent. Among the known loci, BTBD9 seems to be the most consistent in its effect on RLS across populations and is also most independent of familial clustering.
Trvalý link: http://hdl.handle.net/11104/0176913