Počet záznamů: 1
Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor
- 1.0330473 - ÚEM 2010 RIV NL eng J - Článek v odborném periodiku
Valovičová, Z. - Marvanová, S. - Mészárosová, M. - Strančíková, A. - Trilecová, L. - Milcová, Alena - Líbalová, Helena - Vondráček, J. - Machala, M. - Topinka, Jan - Gábelová, A.
Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 665, 1-2 (2009), s. 51-60. ISSN 0027-5107
Grant CEP: GA MŠMT 2B08005; GA MŽP(CZ) SP/1B3/8/08
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: DNA adducts * DNA strand breaks * oxidative stress
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 3.556, rok: 2009
The qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 cells were demonstrated. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC.
Trvalý link: http://hdl.handle.net/11104/0176256
Počet záznamů: 1