Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom

0328907 - ÚOCHB 2010 RIV DE eng J - Článek v odborném periodiku
Dračínský, Martin - Holý, Antonín - Jansa, Petr - Kovačková, Soňa - Buděšínský, Miloš
Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom.
European Journal of Organic Chemistry. -, č. 24 (2009), s. 4117-4122. ISSN 1434-193X. E-ISSN 1099-0690
Grant CEP: GA AV ČR KJB400550903
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: isotopes * NMR spectroscopy * pyrimidines
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.096, rok: 2009

Anotace angl: The proton to deuterium exchange reaction of hydrogen atom in position 5 of the fifteen pyrimidine derivatives was studied. The exchange proceeds under both acidic and alkaline conditions: under acidic conditions, the mechanism involves protonation at position 5 (forming a s-complex), whereas under alkaline conditions, the exchange is caused mainly by the equilibrium of the tautomers involving one tautomer with a sp3 -hybridised carbon atom in position 5.
Trvalý link: http://hdl.handle.net/11104/0175095