Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells

0328368 - MBÚ 2010 RIV US eng J - Článek v odborném periodiku
Kuželová, K. - Grebeňová, D. - Pluskalová, M. - Kavan, Daniel - Halada, Petr - Hrkal, Z.
Isoform-Specific Cleavage of 14-3-3 Proteins in Apoptotic JURL-MK1 Cells.
Journal of Cellular Biochemistry. Roč. 106, č. 4 (2009), s. 673-681. ISSN 0730-2312. E-ISSN 1097-4644
Grant CEP: GA MZd NR9243
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: k562 * apoptosis * 14-3-3
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.935, rok: 2009

The proteins of 14-3-3 family are substantially involved in the regulation of many biological processes including the apoptosis. We studied the changes in the expression of five 14-3-3 isoforms during the apoptosis of JURL-MK1 and K562 cells. The expression level of all these proteins markedly decreased in relation with the apoptosis progression and all isoforms underwent truncation, which probably corresponds to the removal of several C-terminal amino acids. The observed 14-3-3 modifications were partially blocked by caspase-3 inhibition
Trvalý link: http://hdl.handle.net/11104/0174698