Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes

0191416 - UMG-J 20010488 RIV US eng J - Článek v odborném periodiku
Kropshofer, H. - Spindeldreher, S. - Rohn, T. A. - Platania, N. - Grygar, C. - Daniel, N. - Wolpl, A. - Langen, H. - Hořejší, Václav - Vogt, A. B.
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes.
Nature Immunology. Roč. 3, č. 1 (2002), s. 61-68. ISSN 1529-2908. E-ISSN 1529-2916
Výzkumný záměr: CEZ:AV0Z5052915
Klíčová slova: MHC II * tetraspan microdomains * peptide presentation
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 27.868, rok: 2002

Subsets of MHC class II molecules localize to membrane microdomains together with tetraspan proteins, HLA-DM and the costimulator CD86. Tetraspan microdomains enrich MHC class II molecules carrying a selected set of peptide antigens .Antigen-presenting cells deficient in tetraspan microdomains have a reduced capacity to activate CD4+ T cells.
Trvalý link: http://hdl.handle.net/11104/0087169