Alarmin HMGB1 is released in the small intestine of gnotobiotic piglets infected with enteric pathogens and its level in plasma reflects severity of sepsis

0369569 - MBÚ 2012 RIV US eng J - Článek v odborném periodiku
Šplíchalová, Alla - Šplíchal, Igor - Chmelařová, Petra - Trebichavský, Ilja
Alarmin HMGB1 is released in the small intestine of gnotobiotic piglets infected with enteric pathogens and its level in plasma reflects severity of sepsis.
Journal of Clinical Immunology. Roč. 31, č. 3 (2011), s. 488-497. ISSN 0271-9142. E-ISSN 1573-2592
Grant CEP: GA MŠMT ME 915
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: HMGB1 * enteric infection * cytokines
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 3.077, rok: 2011

High mobility group box 1 (HMGB1) is essential for correct DNA folding and transcription and can be released from damaged cells or secreted by stimulated cells. One-week-old germ-free piglets were orally infected/colonized with enteric bacterial pathogens (Salmonella Typhimurium or Escherichia coli O55) or with probiotic bacteria (E. coli Nissle 1917) for 24 h. The local and systemic expression of HMGB1 is a suitable marker of severity of sepsis in the gnotobiotic piglet infection model
Trvalý link: http://hdl.handle.net/11104/0203600