Počet záznamů: 1
Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal
- 1.0369475 - FGÚ 2012 RIV NL eng J - Článek v odborném periodiku
Ujčíková, Hana - Dlouhá, Kateřina - Roubalová, Lenka - Vošahlíková, Miroslava - Kagan, Dmytro - Svoboda, Petr
Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal.
Biochimica et Biophysica Acta-General Subjects. Roč. 1810, č. 12 (2011), s. 1220-1229. ISSN 0304-4165. E-ISSN 1872-8006
Grant CEP: GA MŠMT(CZ) LC554; GA MŠMT(CZ) LC06063; GA ČR(CZ) GD305/08/H037
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: morphine * long-term adaptation * adenylyl cyclase isoforms I–IX * forebrain cortex * isolated plasma membranes
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 5.000, rok: 2011
We assume that the specific increase in expression level of ACI and ACII in brain cortex of morphine-adapted rats proceeds as a compensatory, homeostatic response to prolonged exposure to inhibitory drug, morphine. Our findings demonstrate that the dramatic and specific change of the crucial component of the opioid receptor cascade in brain cortex, manifested as an increase in PM level of ACI and II, is reversible
Trvalý link: http://hdl.handle.net/11104/0203528
Počet záznamů: 1