Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor

0369138 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Jindřichová, Marie - Khafizov, K. - Skorinkin, A. - Fayuk, D. - Bart, G. - Zemková, Hana - Giniatullin, R.
Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.
Journal of Neurochemistry. Roč. 119, č. 4 (2011), s. 676-685. ISSN 0022-3042. E-ISSN 1471-4159
Grant CEP: GA AV ČR(CZ) IAA500110910
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: purinergic receptors * desensitization * patch clamp
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 4.061, rok: 2011

Purinergic P2X receptors are ubiquitous, ligand-gated cationic channels activated by extracellular ATP. The P2X3 receptors, which are involved in nociception, are known for their very fast and complete desensitization, which persists for many minutes. Structural modeling followed by experimental validation of predictions suggested conserved tyrosine 37side chain is needed for the stabilization of the closed receptor state while kinetic modeling specifies that lack of Y37 results in destabilization of closed desensitized states
Trvalý link: http://hdl.handle.net/11104/0203279