Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?

0367669 - ÚEM 2012 RIV GB eng J - Článek v odborném periodiku
Olabarria, M. - Noristani, H. N. - Verkhratsky, Alexei - Rodríguez Arellano, Jose Julio
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: Mechanism for deficient glutamatergic transmission?
Molecular Neurodegeneration. Roč. 6, č. 1 (2011), s. 55-63. E-ISSN 1750-1326
Grant CEP: GA ČR GA309/09/1696; GA ČR(CZ) GAP304/11/0184; GA ČR GA305/08/1384; GA ČR GA309/08/1381
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: astroglia * glutamine synthetase * Alzheimer?'?s disease
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.278, rok: 2011

Here, we report a decline in astrocytic glutamine synthetase (GS) in two major cognitive areas of the hippocampus (the dentate gyrus, DG and the CA1) in 3xTg-AD animals) aged between 9 and 18 months. Such a decrease in astrocytic GS is directly associated with the presence of Aβ deposits indicating AD-related impairments of glutamate homeostatic system, at the advanced and late stages of the disease, which may affect the efficacy of glutamatergic transmission in the diseased brain that may contribute to the cognitive deficiency.
Trvalý link: http://hdl.handle.net/11104/0202262