TGF-beta1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNA12/slug

0366426 - BFÚ 2012 RIV US eng J - Článek v odborném periodiku
Slabáková, Eva - Pernicová, Zuzana - Slavíčková, Eva - Staršíchová, Andrea - Kozubík, Alois - Souček, Karel
TGF-beta1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNA12/slug.
Prostate. Roč. 71, č. 12 (2011), s. 1332-1343. ISSN 0270-4137. E-ISSN 1097-0045
Grant CEP: GA ČR(CZ) GA310/07/0961; GA ČR(CZ) GD303/09/H048; GA MZd NS9600; GA MZd NS9956
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: epithelial-mesenchymal transition * SNAI2/Slug * transforming growth factor-beta1
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.485, rok: 2011

Epithelial-mesenchymal transition (EMT) is involved in physiological processes ranging from embryonic development to tissue remodeling, regeneration, organ fibrosis, cancer progression and metastasis. In this study, we focus on the kinetics of expression of EMT markers and both transcription factors and miRNAs regulating the EMT process in the BPH-1 cell line and in tumorigenic clones derived from this cell line. To the best of our knowledge, this is the first detailed description of EMT regulation in a non-transformed, immortalized epithelial cell line of prostate origin.
Trvalý link: http://hdl.handle.net/11104/0201427