Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions

0365161 - ÚMCH 2012 RIV US eng J - Článek v odborném periodiku
Macková, Hana - Proks, Vladimír - Horák, Daniel - Kučka, Jan - Trchová, Miroslava
Magnetic poly(N-propargylacrylamide) microspheres: preparation by precipitation polymerization and use in model click reactions.
Journal of Polymer Science. Part A - Polymer Chemistry. Roč. 49, č. 22 (2011), s. 4820-4829. ISSN 0887-624X. E-ISSN 1099-0518
Grant CEP: GA AV ČR KJB400500904; GA AV ČR(CZ) KAN401220801; GA ČR GAP503/10/0664
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: click chemistry * magnetic * microspheres
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 3.919, rok: 2011

Magnetic poly(N-propargylacrylamide) (PPRAAm) microspheres were prepared by the precipitation polymerization of N-propargylacrylamide in a toluene/propan-2-ol medium in the presence of magnetic nanoparticles. The effects of polymerization parameters, including the polarity of the medium, polymerization temperature, the concentration of monomer, and the amount of magnetite in the polymerization feed, were examined. The microspheres were characterized in terms of their morphology, size, distribution, and iron content using TEM, SEM and AAS. As expected, Oleic acid-coated Fe3O4 nanoparticles contributed to the stabilization of the magnetic microspheres. Alkyne groups in magnetic PPRAAm microspheres were detected by IR. Microspheres were used as the anchor to enable a ‘‘click’’ reaction with an azido-end-functionalized model peptide (radiolabeled azidopentanoyl-GGGRGDSGGGY(125I)-NH2) and 4-azidophenylalanine using a Cu(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction in water.
Trvalý link: http://hdl.handle.net/11104/0006584