6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs

0363423 - ÚOCHB 2012 RIV NL eng J - Článek v odborném periodiku
de Jersey, J. - Holý, Antonín - Hocková, Dana - Naesens, L. - Keough, D. T. - Guddat, L. W.
6-Oxopurine Phosphoribosyltransferase: A Target for the Development of Antimalarial Drugs.
Current Topics in Medicinal Chemistry. Roč. 11, č. 16 (2011), s. 2085-2102. ISSN 1568-0266. E-ISSN 1873-4294
Grant CEP: GA MŠMT 1M0508
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: Malaria * acyclic nucleoside phosphonates * hypoxanthine * guanine phosphoribosyl transferase
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 4.174, rok: 2011

Plasmodium falciparum and Plasmodium vivax are the predominant causative agents of malaria. One metabolic pathway crucial for the survival and replication and survival of the parasite is the synthesis of the purine nucleoside monophosphates. The focus of this review is on the identification and characterization of inhibitors of the key enzyme in this pathway - 6-oxopurine phosphoribosyltransferase. The acyclic nucleoside phosphonates (ANPs) appear to be excellent candidates that can be selective compared to the human enzyme.
Trvalý link: http://hdl.handle.net/11104/0006532