Japanese encephalitis virus: from genome to infectome

0359440 - BC 2012 RIV NL eng J - Článek v odborném periodiku
Unni, S. K. - Růžek, Daniel - Chhatbar, C. - Mishra, R. - Johri, M. K. - Singh, S. K.
Japanese encephalitis virus: from genome to infectome.
Microbes and Infection. Roč. 13, č. 4 (2011), 312-321. ISSN 1286-4579. E-ISSN 1769-714X
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: Japanese encephalitis * Neurotropic infection * Neuropathogenesis * Mosquito borne infections * Arboviral infections
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 3.101, rok: 2011

Japanese encephalitis virus (JEV) is an arbovirus belonging to the family Flaviviridae. It is maintained in a zoonotic cycle involving pigs, ardeid birds and Culex species of mosquitoes. Humans are accidental/dead end hosts of JEV infection because they cannot sustain high viral titers. Factors affecting the clinical manifestations and pathogenesis of JEV infection are not well understood. Though, vaccines are currently available against JEV, it has to be further improved. Here we review the literature on the JEV life cycle, pathogenesis and host immune responses to JEV infection.
Trvalý link: http://hdl.handle.net/11104/0197230