Thermoresponsive polymeric radionuclide delivery system - an injectable brachytherapy

0359030 - ÚMCH 2012 RIV NL eng J - Článek v odborném periodiku
Hrubý, Martin - Poučková, P. - Zadinová, M. - Kučka, Jan - Lebeda, Ondřej
Thermoresponsive polymeric radionuclide delivery system - an injectable brachytherapy.
European Journal of Pharmaceutical Sciences. Roč. 42, č. 5 (2011), s. 484-488. ISSN 0928-0987. E-ISSN 1879-0720
Grant CEP: GA ČR GPP207/10/P054; GA AV ČR IAAX00500803; GA MŠMT 1M0505; GA MŠMT 2B06165
Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z10480505
Klíčová slova: thermoresponsive polymer * brachytherapa * drug delivery
Kód oboru RIV: CD - Makromolekulární chemie
Impakt faktor: 3.212, rok: 2011

Brachytherapy is of increasing popularity in clinical oncology for the local therapy of solid tumors due to high radiation doses delivered to malignant tissue while keeping the whole-body radiation burden low. Pronounced dose-dependent tumor growth reduction was achieved by single dose of injectable intratumoral brachytherapy with iodine-131-labeled thermoresponsive polymer [poly(N-isopropyl acrylamide)] in murine xenograft model (PC3 human prostate adenocarcinoma). Such injectable system should keep advantages of brachytherapy while making system administration easier and less invasive (injection instead of implantation), patient-tailored (splitting of doses into several depoes) and bioerodable.
Trvalý link: http://hdl.handle.net/11104/0006420