Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells

0359013 - BFÚ 2012 RIV NL eng J - Článek v odborném periodiku
Procházková, Jiřina - Kozubík, Alois - Machala, M. - Vondráček, Jan
Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells.
Toxicology. Roč. 279, 1-3 (2011), s. 146-154. ISSN 0300-483X
Grant CEP: GA ČR(CZ) GA524/06/0517
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: indirubin * aryl hydrocarbon receptor * plakoglobin
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 3.681, rok: 2011

Effects of indirubin, a putative novel ligand of aryl hydrocarbon receptor, had been tested in an in vitro model of rat oval cells, and compared with the effects of model toxic ligand, TCDD. We observed dose-sependent differences in indirubin action on AhR activation and on expression of selected genes known to be regulated by AhR/ARNT signaling pathway.
Trvalý link: http://hdl.handle.net/11104/0196892