IrAM—An .alpha..sub.2./sub.-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes

0358930 - BC 2011 RIV GB eng J - Článek v odborném periodiku
Burešová, Veronika - Hajdušek, Ondřej - Franta, Zdeněk - Sojka, Daniel - Kopáček, Petr
IrAM—An .alpha.₂-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes.
Developmental and Comparative Immunology. Roč. 33, č. 4 (2009), s. 489-198. ISSN 0145-305X. E-ISSN 1879-0089
Grant CEP: GA AV ČR IAA600220603
Klíčová slova: α2-macroglobulin * tick * phagocytosis
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.290, rok: 2009

We have cloned, sequenced and characterized an macromolecular protease inhibitor of α2-macroglobulin family from the hard tick Ixodes ricinus named IrAM. Using the tool of RNA interference we have demonstrated that IrAM is an important constituent of tick innate immunity since it is involved in the phagocytosis of the pathogen Chryseobacterium indologenes by tick hemocytes. This is the first evidence showing that a cellular immune response in invertebrates is linked with interaction of an plasma α2-macroglobulin with protease derived from invading pathogen.
Trvalý link: http://hdl.handle.net/11104/0196831