Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease

0357625 - ÚEM 2011 RIV GB eng J - Článek v odborném periodiku
Rodríguez Arellano, Jose Julio - Witton, J. - Olabarria, M. - Noristani, H. N. - Verkhratsky, Alexei
Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer´s disease.
Cell Death & Disease. Roč. 1, č. 1 (2010), e1-e6. ISSN 2041-4889. E-ISSN 2041-4889
Grant CEP: GA ČR GA309/09/1696; GA ČR GA305/08/1384
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: microglia * Alzheimer´s disease * hippocampus
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 0.000, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0357625_01.pdf

Our results show for the first time that the increase in the density of resting microglia precedes both plaque formation and activation of microglia by extracellular Aβ accumulation. We suggest that AD pathology triggers a complex microglial reaction: at the initial stages of the disease the number of resting microglia increases, as if in preparation for the ensuing activation in an attempt to fight the extracellular Aβ load that is characteristic of the terminal stages of the disease.
Trvalý link: http://hdl.handle.net/11104/0195858