Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs

0353069 - ÚŽFG 2011 RIV US eng J - Článek v odborném periodiku
Usvald, Dušan - Vodička, Petr - Hlučilová, Jana - Procházka, Radek - Motlík, Jan - Kuchorova, K. - Johe, K. - Marsala, S. - Scadeng, M. - Kakinohana, O. - Navarro, R. - Santa, M. - Hefferan, M. P. - Yaksh, T.L. - Marsala, M.
Analysis of dosing regimen and reproducibility of intraspinal grafting of human spinal stem cells in immmunosuppressed minipigs.
Cell Transplantation. Roč. 19, č. 9 (2010), s. 1103-1122. ISSN 0963-6897. E-ISSN 1555-3892
Výzkumný záměr: CEZ:AV0Z50450515
Klíčová slova: minipigs * human spinal stem cells * analysis
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 6.204, rok: 2010

In recent studies using a rat aortic balloon occlusion model, we have demonstrated that spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to progressive amelioration of spasticity and rigidity and corresponding improvement in ambulatory function. In the present study, we characterized the optimal dosing regimen and safety profile of human spinal stem cells (HSSC) when grafted into the lumbar spinal cord segments of naive immunosuppressed minipigs
Trvalý link: http://hdl.handle.net/11104/0192413