Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation

0350954 - ÚOCHB 2011 RIV GB eng J - Článek v odborném periodiku
Hiraoka, N. - Ino, Y. - Sekine, S. - Tsuda, H. - Shimada, K. - Kosuge, T. - Závada, Jan - Yoshida, M. - Yamada, K. - Koyama, T. - Kanai, Y.
Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation.
British Journal of Cancer. Roč. 103, č. 7 (2010), s. 1057-1065. ISSN 0007-0920. E-ISSN 1532-1827
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: pancreatic cancer * hypoxia * prognostics
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.831, rok: 2010

Hypoxia is a major factor of increased invasivity of cancer, resulting in a poor prognosis. In tumor sections, it is manifested by necrotic foci and expression of CAIX protein. We investigated 248 patients with pancreatic ductal carcinoma and correlated necrosis and CAIX with the lenght of survival. SAIX is a biomarker which can easily be evaluated by independent scientists.
Trvalý link: http://hdl.handle.net/11104/0190811