Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

0350688 - ÚEM 2011 RIV US eng J - Článek v odborném periodiku
Albizu, L. - Cottet, M. - Králíková, Michaela - Stoev, S. - Steyer, R. - Brabet, I. - Roux, T. - Bazin, H. - Bourrier, E. - Lamarque, L. - Breton, C. - Rives, M. L. - Newman, A. H. - Javitch, J. A. - Trinquet, E. - Manning, M. - Pin, J. P. - Mouillac, B. - Durroux, T.
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.
Nature Chemical Biology. Roč. 6, č. 8 (2010), s. 587-594. ISSN 1552-4450. E-ISSN 1552-4469
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: G protein-coupled receptor * FRET
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 15.808, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0350688_01.pdf

The artical "Time-resolved FRET between GPCR ligands reveals oligomers in native tissues" shows for the first time that G-protein coupled receptors (GPCRs) form oligomeric complexes also in native tissues and not only in heterologous expression systems. Oligomerization of these receptors regulates their function and pharmacological properties and thus influences all the processes controled by GPCRs that are involved in the cell response to extracellular stimuli.
Trvalý link: http://hdl.handle.net/11104/0190624