Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS

0348934 - ÚEM 2011 RIV US eng J - Článek v odborném periodiku
Bekku, Y. - Vargová, Lýdia - Goto, Y. - Voříšek, Ivan - Dmytrenko, Lesia - Narasaki, M. - Ohtsuka, A. - Fässler, R. - Ninomiya, Y. - Syková, Eva - Oohashi, T.
Bral1: Its Role in Diffusion Barrier Formation and Conduction Velocity in the CNS.
Journal of Neuroscience. Roč. 30, č. 8 (2010), s. 3113-3123. ISSN 0270-6474. E-ISSN 1529-2401
Grant CEP: GA ČR GA309/09/1597
Grant ostatní: GA MŠk(CZ) 1M0538; GA MZd(CZ) NS9915
Program: 1M
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: Bral1 * central nervous system * brain development
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 7.271, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0348934_01.pdf

Brain-specific hyaluronan-binding link protein, Bral1, colocalizes and forms complexes with negatively charged extracellular matrix (ECM) proteins at the nodes of Ranvier in the myelinated white matter. The study report that the ECM no longer shows a nodal pattern and that CNS nerve conduction is markedly decreased in Bral1-deficient mice and the changes in the extracellular space diffusion parameters, measured by the real-time iontophoretic method and diffusion-weighted magnetic resonance imaging (MRI), suggest a reduction in the diffusion hindrances in the white matter of mutant mice.
Trvalý link: http://hdl.handle.net/11104/0189315