Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia

0345750 - FGÚ 2011 RIV US eng J - Článek v odborném periodiku
Smolková, Katarína - Bellance, N. - Scandurra, F. - Génot, E. - Gnaiger, E. - Plecitá-Hlavatá, Lydie - Ježek, Petr - Rossignol, R.
Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia.
Journal of Bioenergetics and Biomembranes. Roč. 42, č. 1 (2010), s. 55-67. ISSN 0145-479X. E-ISSN 1573-6881
Grant CEP: GA AV ČR(CZ) IAA500110701
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: mitochondria * oxidative phosphorylation * breast cancer
Kód oboru RIV: CE - Biochemie
Impakt faktor: 3.637, rok: 2010

Breasts cancer cells can survive and proliferate under harsh conditions of nutrient deprivation, including limited oxygen and glucose availability. Here, we mimicked aglycemia and hypoxia in vitro and compared the mitochondrial and cellular bioenergetic adaptation of human breast cancer (HTB-126) and non-cancer (HTB-125) cells that originate from breast tissue. The data demonstrate that cancer cells behave differently than normal cells when adapting their bioenergetics to microenviromental conditions
Trvalý link: http://hdl.handle.net/11104/0186950