Role of matrix metalloproteinases in recurrent corneal melting

0345733 - ÚEM 2011 RIV GB eng J - Článek v odborném periodiku
Brejchová, K. - Lisková, P. - Čejková, Jitka - Jirsová, K.
Role of matrix metalloproteinases in recurrent corneal melting.
Experimental Eye Research. Roč. 90, č. 5 (2010), s. 583-590. ISSN 0014-4835. E-ISSN 1096-0007
Výzkumný záměr: CEZ:AV0Z50390512
Klíčová slova: corneal melting * extracellular matrix degradation * matrix metalloproteinases
Kód oboru RIV: FF - ORL, oftalmologie, stomatologie
Impakt faktor: 2.817, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0345733_01.pdf

The aim of the study was to investigate the role of metalloproteinases (MMPs - 1,- 2, -3, -4, -5,- 6,- 7, -8,- 9 and -13) during corneal melting in humans. The markety increased immunostaining for MMPS -1,- 2,- 3, -7, -8 and -9 and increased levels of the activity of MMP-1, -2, -3 and -9 in melted corneas of patiens suffering from various ocular diseases suggest that metalloproteinases play very important role in the destruction of extracellular matrix leading to corneal melting.
Trvalý link: http://hdl.handle.net/11104/0186936