WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance

0341448 - MBÚ 2010 RIV SK eng J - Článek v odborném periodiku
Otahalová, E. - Ullmannová-Benson, Veronika - Klamová, H. - Haškovec, C.
WT1 expression in peripheral leukocytes of patients with chronic myeloid leukemia serves for the prediction of Imatinib resistance.
Neoplasma. Roč. 56, č. 5 (2009), s. 393-397. ISSN 0028-2685. E-ISSN 1338-4317
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: Imatinib * drug resistance * cml
Kód oboru RIV: EC - Imunologie
Impakt faktor: 1.192, rok: 2009

The determination of patient's resistance to a particular drug contributes to more efficient therapeutical approach. The aim of this study was to evaluate if the responsiveness of Chronic Myeloid Leukemia (CML) patients to Imatinib therapy was predictable from WT1 gene expression in peripheral blood leukocytes. To examine the resistance we implemented an in vitro cultivation of the primary cells of 48 CML patients with Imatinib
Trvalý link: http://hdl.handle.net/11104/0184440