Počet záznamů: 1
Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors
- 1.0339074 - FGÚ 2010 RIV GB eng J - Článek v odborném periodiku
Jakubík, Jan - Randáková, Alena - El-Fakahany, E. E. - Doležal, Vladimír
Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.
B M C Pharmacology. Roč. 9, č. 15 (2009), s. 1-20. ISSN 1471-2210
Grant CEP: GA ČR GA305/09/0681; GA MŠMT(CZ) LC554; GA AV ČR(CZ) IAA500110703
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: muscarinic receptors * allosteric modulation * rapacuronium
Kód oboru RIV: ED - Fyziologie
Albeit rapacuronium decreases affinity of acetylcholine under equilibrium conditions it accelerates acetylcholine binding. This results in potentiation of receptor activation by acetylcholine at low concentrations of rapacuronium. These observations highlight the necessity of performing functional tests under non-equilibrium conditions that resemble physiological conditions
Trvalý link: http://hdl.handle.net/11104/0182683
Počet záznamů: 1