Počet záznamů: 1
Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group
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SYSNO ASEP 0383763 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group Tvůrce(i) Aliota, M. T. (US)
Jones, S. A. (US)
Dupuis, A. P. (US)
Ciota, A. T. (US)
Hubálek, Zdeněk (UBO-W) RID, SAI, ORCID
Kramer, L. D. (US)Celkový počet autorů 6 Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 7, č. 6 (2012), e39387Poč.str. 6 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Insect-specific flaviviruses ; Northeastern United-States ; Culex pipiens Vědní obor RIV EE - Mikrobiologie, virologie Institucionální podpora UBO-W - RVO:68081766 UT WOS 000305652700075 EID SCOPUS 84862526803 DOI 10.1371/journal.pone.0039387 Anotace Rabensburg virus (RABV), a Flavivirus with similar to 76% nucleotide and 90% amino acid identity with representative members of lineage one and two West Nile virus (WNV), previously was isolated from Culex pipiens and Aedes rossicus mosquitoes in the Czech Republic, and phylogenetic and serologic analyses demonstrated that it was likely a new lineage of WNV. However, no direct link between RABV and human disease has been definitively established and the extent to which RABV utilizes the typical WNV transmission cycle is unknown. Herein, we evaluated vector competence and capacity for vertical transmission (VT) in Cx. pipiens; in vitro growth on avian, mammalian, and mosquito cells; and infectivity and viremia production in birds. RABV infection and replication only were detected on mosquito cells. Experimentally inoculated birds did not become infected. Cx. pipiens had poor peroral vector competence and a higher VT rate as compared to US-WNV in Cx. pipiens. As a result, we postulate that RABV is an intermediate between the mosquito-specific and horizontally transmitted flaviviruses. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2013
Počet záznamů: 1