Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis

0368248 - ÚEM 2012 RIV GB eng J - Článek v odborném periodiku
Forostyak, Serhiy - Jendelová, Pavla - Kapcalová, Miroslava - Arboleda Toro, David - Syková, Eva
Mesenchymal stromal cells prolong the lifespan in a rat model of amyotrophic lateral sclerosis.
Cytotherapy. Roč. 13, č. 9 (2011), s. 1036-1046. ISSN 1465-3249. E-ISSN 1477-2566
Grant CEP: GA MŠMT(CZ) LC554; GA ČR(CZ) GAP304/11/0189
Grant ostatní: GA MŠk(CZ) 1M0538; GA ČR(CZ) GD309/08/H079
Program: 1M
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: motor neurons * neurodegenerative diseases * stem cells
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 3.627, rok: 2011

In current study transgenic rats overexpressing mutant human SOD1 were used as a model of fALS. We have found that grafting of MSC into symptomatic rats had a significant effect on motor activity and grip strength and longer lifespan if compared with the control group of animals. Transplanted cells survived and migrated in the spinal cord until the end stage of the disease without any side effects. Combined delivery of BM-derived MSC, therefore, could be an attractive approach for bench-to bedside studies in the treatment of ALS.
Trvalý link: http://hdl.handle.net/11104/0202644