Computational Modelling of Catalytic Properties and Modified Substrates of Fungal B-N-Acetylhexosaminidases

0366489 - MBÚ 2012 RIV AE eng J - Článek v odborném periodiku
Kulik, Natallia - Slámová, Kristýna
Computational Modelling of Catalytic Properties and Modified Substrates of Fungal B-N-Acetylhexosaminidases.
Mini - Reviews in Organic Chemistry. Roč. 8, č. 3 (2011), s. 270-280. ISSN 1570-193X. E-ISSN 1875-6298
Grant CEP: GA ČR(CZ) GAP207/11/0629; GA ČR GD305/09/H008; GA MŠMT(CZ) LC06010
Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z60870520
Klíčová slova: beta-N-Acetylhexosaminidase * computer modelling * modified substrate
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.406, rok: 2011

Besides their implication in human physiology and disease, b-N-acetylhexosaminidases (EC 3.2.1.52, CAZy GH 20) have recently gained a lot of attention thanks to their great potential in the enzymatic synthesis of carbohydrates and glycomimetics. Extracellular b -N-acetylhexosaminidases from filamentous fungi proved to be a powerful synthetic tool for the preparation of both natural and modified glycosides under mild conditions with good yields. A homology model of b-N-acetylhexosaminidase from the filamentous fungus Aspergillus oryzae has recently been reported, and its quality was corroborated by vibrational spectroscopy and biochemical studies
Trvalý link: http://hdl.handle.net/11104/0201468