Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin

0366149 - BFÚ 2012 RIV GB eng J - Článek v odborném periodiku
Mikeš, J. - Hýžďalová, Martina - Kočí, Lenka - Jendželovský, R. - Koval, J. - Vaculová, Alena - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, P.
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.
Photochemical & Photobiological Sciences. Roč. 10, č. 4 (2011), s. 626-632. ISSN 1474-905X. E-ISSN 1474-9092
Grant CEP: GA ČR(CZ) GA301/07/1557
Grant ostatní: GA ČR(CZ) GA305/09/1526
Program: GA
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: photodynamic therapy * hypericin * colon cancer
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 2.584, rok: 2011

Hypericin (HY) has found applications in photodynamic diagnostics solely due to its high specificity for tumour cells and tissues. We showed that despite the higher accumulation of HY in FHC human fetal colon epithelial cells compared to HT-29 colon adenocarcinoma cells, the cytotoxic effects of this photosensitizer were more pronounced in the latter cell line, and this was associated with enhanced accumulation of HY-induced reactive oxygen species (ROS).
Trvalý link: http://hdl.handle.net/11104/0201224