The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure

0365117 - ÚMG 2012 RIV AU eng J - Článek v odborném periodiku
Rohoušová, I. - Hostomská, J. - Vlková, M. - Kobets, Tetyana - Lipoldová, Marie - Volf, P.
The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure.
International Journal for Parasitology. Roč. 41, č. 5 (2011), s. 481-485. ISSN 0020-7519. E-ISSN 1879-0135
Grant CEP: GA MŠMT(CZ) LC06009
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: Phlebotomus duboscqi * Leishmania major * anti-saliva IgG
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.393, rok: 2011

Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva.
Trvalý link: http://hdl.handle.net/11104/0200435