Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus

0364792 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Zemková, Hana - Stojilkovič, S.S. - Klein, D. C.
Norepinephrine Causes a Biphasic Change in Mammalian Pinealocye Membrane Potential: Role of alfa1B-Adrenoreceptors, Phospholipase C, and Ca2plus.
Endocrinology. Roč. 152, č. 10 (2011), s. 3842-3851. ISSN 0013-7227. E-ISSN 1945-7170
Grant CEP: GA ČR(CZ) GA305/07/0681
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: Ca2plus-activated Kplus channels * voltage-gated Ca2plus channels * electrical activity * pinealocyte
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 4.459, rok: 2011

The pineal gland is a neuroendocrine transducer, which generates a nocturnal increase in melatonin production, reflecting stimulation by norepinephrine (NE). NE was found to act through alpha1B-adrenoreceptors in a concentration-dependent manner to produce a biphasic change in membrane potential: initial transient hyperpolarization is followed by stable depolarization. These observations indicate that both continuous elevation of intracellular Ca2plus and sustained depolarization are associated with and are likely to be required for activation of the pinealocyte
Trvalý link: http://hdl.handle.net/11104/0200178