Similarity of fine specificity of IgA-gliadin antibodies between patients with celiac disease and humanized α 1KI mice

0361616 - MBÚ 2012 RIV US eng J - Článek v odborném periodiku
Sánchez, Daniel - Champier, G. - Cuvillier, A. - Cogné, M. - Pekáriková, Aneta - Tlaskalová, Helena - Hoffmanová, I. - Drastich, P. - Mothes, T. - Tučková, Ludmila
Similarity of fine specificity of IgA-gliadin antibodies between patients with celiac disease and humanized α 1KI mice.
Journal of Agricultural and Food Chemistry. Roč. 59, č. 7 (2011), 3092-3100. ISSN 0021-8561. E-ISSN 1520-5118
Grant CEP: GA AV ČR IAA500200709; GA ČR GA310/07/0414
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: alpha 1KI mouse * IgA antibodies * celiac disease
Kód oboru RIV: EC - Imunologie
Impakt faktor: 2.823, rok: 2011

Gliadins, and primarily a-gliadins containing several sequences such as aa 31-49, aa 56-88 (33-mer), aa 57-68, and aa 69-82, are critical in the induction of immune response or toxic reaction leading to the development of celiac disease (CLD). The role of IgA anti-gliadin antibodies (IgA AGA) is unknown. To this end, we prepared several humanized monoclonal IgA AGA using transgenic α1KI mice. Employing Pepscan with overlapping decapeptides of a-gliadin we observed a robust similarity between the specificity of humanized mouse monoclonal IgA AGA and IgA AGA from patients with florid CLD
Trvalý link: http://hdl.handle.net/11104/0198893