Počet záznamů: 1
A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates
- 1.0360949 - ÚOCHB 2012 RIV GB eng J - Článek v odborném periodiku
Beier, Petr - Opekar, Stanislav - Zibinsky, M. - Bychinskaya, I. - Prakash, G. K. S.
A new route alpha-alkyl-alpha-fluoromethylenebisphosphonates.
Organic & Biomolecular Chemistry. Roč. 9, č. 11 (2011), s. 4035-4038. ISSN 1477-0520. E-ISSN 1477-0539
Grant CEP: GA ČR GP203/08/P310
Výzkumný záměr: CEZ:AV0Z40550506
Klíčová slova: fluorine * phosphonate * alkylation
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.696, rok: 2011
A new route to alpha-alkyl-alpha-fluoromethylenebisphosphonates (2) has been developed starting from commercially available tetraethyl fluoromethylenebisphosphonate (1), and alkyl halides using either cesium carbonate in DMF or sodium dimsyl. De-esterification of 2 provided biologically important alpha-alkyl-alpha-fluoromethylenebisphosphonic acid (3), while alkoxide–induced carbon–phosphorus bond cleavage of 2 gave alfa-fluorophosphonates (4), which are useful synthons in organic synthesis.
Trvalý link: http://hdl.handle.net/11104/0198381
Počet záznamů: 1