Inositol Trisphosphate-Induced Ca2+ Signaling Modulates Auxin Transport and PIN Polarity

0360769 - ÚEB 2012 RIV US eng J - Článek v odborném periodiku
Zhang, J. - Vanneste, S. - Brewer, P. B. - Michniewicz, M. - Grones, P. - Kleine-Vehn, J. - Löfke, Ch. - Teichmann, T. - Bielach, A. - Cannoot, B. - Hoyerová, Klára - Chen, X. - Xue, H. W. - Benková, E. - Zažímalová, Eva - Friml, J.
Inositol Trisphosphate-Induced Ca2+ Signaling Modulates Auxin Transport and PIN Polarity.
Developmental Cell. Roč. 20, č. 6 (2011), s. 855-866. ISSN 1534-5807. E-ISSN 1878-1551
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: PIN polarity * auxin distribution * Inositol trisphosphate
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 14.030, rok: 2011

Directional auxin flow within tissues depends on polar localization of PIN transporters. To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphate 1-phosphatase mutant (supo1), with elevated inositol trisphosphate (InsP3) and cytosolic Ca2+ levels. Increases in InsP3 or Ca2+ levels also suppressed the PIN1 phenotypes and caused defects in basal PIN localization, auxin transport and auxin mediated development. Reductions in InsP3 levels and Ca2+ signaling antagonized the effects of the supo1 mutation and disrupted preferentially apical PIN localization. InsP3 and Ca2+ are evolutionarily conserved second messengers involved in various cellular functions, particularly stress responses. Our findings implicate them as modifiers of cell polarity and polar auxin transport, and highlight a potential integration point through which Ca2+ signaling-related stimuli could influence auxin-mediated development.
Trvalý link: http://hdl.handle.net/11104/0198241