Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines

0357898 - ÚEB 2011 RIV AT eng J - Článek v odborném periodiku
Gucký, Tomáš - Řezníčková, Eva - Džubák, P. - Hajdúch, M. - Kryštof, Vladimír
Synthesis and anticancer activity of some 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines.
Monatshefte fur Chemie. Roč. 141, č. 6 (2010), s. 709-714. ISSN 0026-9247. E-ISSN 1434-4475
Grant CEP: GA ČR GA204/08/0511; GA ČR GA301/08/1649
Výzkumný záměr: CEZ:AV0Z50380511
Klíčová slova: Pyrazolo[4,3-e][1,2,4]triazine * Anticancer * Cyclin-dependent kinase
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.356, rok: 2010

The deregulation of cell cycle components in cancer cells has provided a rationale for the development of small molecule inhibitors of cyclin-dependent kinases as novel anticancer drugs. A series of 1,5-diaryl-3-(3,4,5-trihydroxyphenyl)-1H-pyrazolo[4,3-e][1,2,4]triazines was synthesized and their kinase inhibitory activity and cytotoxicity against several cancer cell lines has been evaluated. Some of the compounds of the series exhibited induction of caspase-dependent cell death and inhibition of cyclin-dependent kinase 2 (CDK2).
Trvalý link: http://hdl.handle.net/11104/0006387