SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers

0356499 - ÚMCH 2011 RIV GB eng J - Článek v odborném periodiku
Angelov, Borislav - Angelova, A. - Mutafchieva, R. - Lesieur, S. - Vainio, U. - Garamus, V. M. - Jensen, G. V. - Pedersen, J. S.
SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers.
Physical Chemistry Chemical Physics. Roč. 13, č. 8 (2011), s. 3073-3081. ISSN 1463-9076. E-ISSN 1463-9084
Grant CEP: GA ČR GA202/09/2078; GA ČR GAP208/10/1600
Výzkumný záměr: CEZ:AV0Z40500505
Klíčová slova: lipid-water phases * liquid crystals * swelling
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 3.573, rok: 2011

The encapsulation and release of peptides, proteins, nucleic acids, and drugs in nanostructured lipid carriers depend on the type of the self-assembled liquid-crystalline organization and the structural dimensions of the aqueous and membraneous compartments, which can be tuned by the multicomponent composition of the systems. In this work, small-angle X-ray scattering investigation is performed on the ‘melting’ transition of the bicontinuous double diamond cubic phase, formed by pure glycerol monooleate, upon progressive inclusion of varying fractions of pharmaceutical-grade glycerol monooleate in the hydrated system.
Trvalý link: http://hdl.handle.net/11104/0195005