Kinetics of ethanol decay in mouth- and nose-exhaled breath measured on-line by selected ion flow tube mass spectrometry following varying doses of alcohol

0355624 - ÚFCH JH 2011 RIV GB eng J - Článek v odborném periodiku
Smith, D. - Pysanenko, Andriy - Španěl, Patrik
Kinetics of ethanol decay in mouth- and nose-exhaled breath measured on-line by selected ion flow tube mass spectrometry following varying doses of alcohol.
Rapid Communications in Mass Spectrometry. Roč. 24, č. 7 (2010), s. 1066-1074. ISSN 0951-4198. E-ISSN 1097-0231
Grant CEP: GA ČR GA202/09/0800
Výzkumný záměr: CEZ:AV0Z40400503
Klíčová slova: mass spectrometry * blood-alcohol * breath
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 2.846, rok: 2010

A study has been carried out of the decay of ethanol in mouth-exhaled and nose-exhaled breath of two healthy volunteers following the ingestion of various doses of alcohol at different dilutions in water. Concurrent analyses of sequential single breath exhalations from the two volunteers were carried out using selected ion flow tube mass spectrometry, SIFT-MS, on-line and in real time continuously over some 200 min following each alcohol dose by simply switching sampling between the two volunteers. Thus, the time interval between breath exhalations was only a few minutes, and this results in well-defined decay curves. Inspection of the mouth-exhaled and nose-exhaled breath data shows that mouth contamination of ethanol diminished to insignificant levels after a few minutes. The detailed results of the analyses of nose-exhaled breath show that the peak levels and the decay rates of breath ethanol are dependent on the ethanol dose and the volume of ethanol/water mixture ingested.
Trvalý link: http://hdl.handle.net/11104/0006304