NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells

0355236 - BFÚ 2011 RIV US eng J - Článek v odborném periodiku
Krejčí, Pavel - Murakami, S. - Procházková, J. - Trantírek, L. - Chlebová, K. - Ouyang, Z. - Aklian, A. - Smutný, J. - Bryja, Vítězslav - Kozubík, Alois - Wilcox, W.R.
NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells.
Journal of Biological Chemistry. Roč. 285, č. 27 (2010), s. 20644-20653. ISSN 0021-9258. E-ISSN 1083-351X
Grant ostatní: GA ČR(CZ) GA301/09/0587
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: NF449 * fibroblast growth factor receptor * antagonist
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 5.328, rok: 2010

This article indentifies, for the first time, a NF449 compound as a novel inhibitor of FGFR3 signal transduction in vitro and in vivo. Various molecular aspects of NF449 action are described and discussed in the article, such as its effects on FGFR3 kinase activity, activation of downstream signaling molecules as well as effects on several cellular phenotypes regulated by FGFR3 signaling.
Trvalý link: http://hdl.handle.net/11104/0194054