Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97

0351615 - MBÚ 2011 RIV GB eng J - Článek v odborném periodiku
Zelík, Petr - Lukešová, Alena - Čejka, J. - Buděšínský, Miloš - Havlíček, Vladimír - Čegan, A. - Kopecký, Jiří
Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 25, č. 3 (2010), s. 414-420. ISSN 1475-6366. E-ISSN 1475-6374
Grant CEP: GA MŠMT ME 874
Výzkumný záměr: CEZ:AV0Z50200510; CEZ:AV0Z60660521; CEZ:AV0Z40550506
Klíčová slova: Cholinesterase inhibitor * cyclopentenedione * cyanobacteria
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 1.574, rok: 2010

Nostotrebin 6, a new polyphenolic compound with a fully substituted 2,2-bis(cyclopent-4-en-1,3-dione) skeleton, was isolated from a methanolic extract of the cyanobacterial strain Nostoc sp. str. Lukešová 27/97. The structure of this compound was determined using X-ray crystallography and further supported by NMR, IR spectroscopy, and MS. Nostotrebin 6 is an S-parabolic I-parabolic noncompetitive inhibitor of acetylcholinesterase (IC50 is 5.5 microM) and an S-parabolic I-parabolic mixed inhibitor of butyrylcholinesterase (IC50 is 6.1–7.5 microM). The inhibitory potency of nostotrebin 6 was compared with that of tacrine and galanthamine
Trvalý link: http://hdl.handle.net/11104/0191327